June 1, 2023
September 11, 2023
Case Report: Clinical Lung Cancer Journal

The article "Major Clinical Response to Afatinib Monotherapy in Lung Adenocarcinoma Harboring EGFR Exon 20 Insertion Mutation" describes the case study of a patient with advanced non-small cell lung cancer (NSCLC) that had progressed after initial chemotherapy treatment. The patient underwent genomic profiling of their tumor tissue, and the results were analyzed using the computational decision support tool Genomate. The analysis identified a genomic alteration in the tumor that was potentially targetable by an available drug, and the patient was treated with the targeted therapy afatinib. The patient showed a partial response to the treatment, with a reduction in tumor size and improvement in symptoms.

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Urbán L, Dóczi R, Vodicska B, Tihanyi D, Horváth M, Kormos D, Takács I, Pápai-Székely Z, Póka-Farkas Z, Várkondi E, Schwáb R, Hegedüs C, Vályi-Nagy I, Peták I.

Clin Lung Cancer. 2021 Jan;22(1):e112-e115. doi: 10.1016/j.cllc.2020.09.005. Epub 2020 Sep 18. PMID: 33082101.