September 11, 2023
Case Report: JCO Precision Oncology

The article "Lasting Complete Clinical Response of a Recurring Cutaneous Squamous Cell Carcinoma With MEK Mutation and PIK3CA Amplification Achieved by Dual Trametinib and Metformin Therapy" describes a case study of a patient with cutaneous squamous cell carcinoma (cSCC) that had recurred multiple times and had developed resistance to previous treatments. The patient had a genomic profile showing mutations in the MEK and PIK3CA genes, which are known to be involved in cancer progression and resistance to therapy. The patient was treated with a combination of trametinib, a MEK inhibitor, and metformin, a drug commonly used to treat diabetes that has shown potential as an anticancer agent.

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Remenár É, Dóczi R, Dirner A, Sipos A, Perjési A, Tihanyi D, Vodicska B, Lakatos D, Horváth K, Kajáry K, Schwáb R, Déri J, Lengyel CG, Várkondi E, Vályi-Nagy I, Peták I.
JCO Precis Oncol. 2022 Jan;6:e2100344. doi: 10.1200/PO.21.00344. PMID: 35005996.